Elevation of Some Cytokines, CD4 and CD8 in Odontogenic Infection

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Published: May 24, 2023
DOI: https://doi.org/10.47191/ijpbms/v3-i5-09
Keywords:
odontogenic infection, IL-6, INF-ɣ, CD4,CD8

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Rusul Saleem Abd
College of Biotechnology, Al-Qasim Green University, Iraq
Wed Abbas Mohammed
College of Biotechnology, Al-Qasim Green University, Iraq
Ameer Adil Hamza
College of Biotechnology, Al-Qasim Green University, Iraq
Iman Fadhel Abdul –Hussien
College of Biotechnology, Al-Qasim Green University, Iraq
Hamzah H. Kzar
College of veterinary medicine, Al-Qasim Green University, Iraq

Abstract

An odontogenic infection is an infection that originates within a tooth or in the closely surrounding tissues. In vitro quantitative evaluation of. IL-6, INF-gamma and CD4 and. CD8 molecules during odontogenic infection and control. group. In vitro quantitative determination of, IL-6,INF-gamma and CD4 and CD8 molecules in serum using Sandwich-ELISA. the Mean±SD of serum IL-6 was 41.1450±19.802 (pg\ml) for patients and 10.367±4.047 pg\ml for healthy with P. value 0.0001, while the Mean±SD of serum IFN-ɣ was higher in control group than in test group (61.490±30.662) (pg\ml) and 16.880±7.593 (pg\ml) respectively. and the differences were significant, P 0.0001. At the same time, The mean of serum CD4 molecules was 5.175±2.335 (ng\ml) and 2.230±1.027 (ng\ml) for controls groups with P. value was ≤0.0001. while serum soluble CD8 was the Mean±SD 3.265±1.175 (ng\ml) and 1.014±0.815 (ng\ml) for controls healthy with P. value ≤ 0.0001. Mean of the CD4/CD8 ratio was 1.584 in control group while it was 2.199 in odontogenic infection patients"


Conclusion: Immunological parameters were included in present study ( IL-6, IFN-ɣ, CD4 and CD8,) showed high levels among patients with odontogenic infection compared to a healthy control.

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Abd, R. S. ., Mohammed, W. A. ., Hamza, A. A. ., –Hussien, I. F. A. ., & Kzar, H. H. . (2023). Elevation of Some Cytokines, CD4 and CD8 in Odontogenic Infection. International Journal of Pharmaceutical and Bio Medical Science, 3(05), 215–218. https://doi.org/10.47191/ijpbms/v3-i5-09
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Vol. 3 No. 05 (2023): Volume 03 Issue 05 May 2023
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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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